Effectiveness of Marine Bioactive Compound Fucoidan in Stimulating Osteoblast Cells Formation: A Systematic Review

BACKGROUND: Bone loss in the oral cavity can occur various situations, including periodontitis-related issues and complications after tooth extraction. A damaged or lost alveolar bone be restored through a tissue engineering approach. Fucoidan, marine biopolymer derived from brown algae, is one biomaterial that aids regeneration since it contains biomaterials generate new osteoblast cells. AIM: The purpose of this review to determine whether fucoidan employed promote cell growth during repair. METHODS: search strategy was performed PubMed; Elsevier (Scopus); ScienceDirect; Libgen, Google Scholar. In addition, manual hand searching locate identify additional studies. RESULTS: Based on reviewed articles, has been discovered five met inclusion criteria found bioactive compound significantly increase expression ALP activity. CONCLUSION: Fucoidan considered have biological properties, antithrombotic, anticoagulant, antioxidant. It also serves as phenotypic marker early stages osteoblastic differentiation.